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Article

Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast.

Genes & development - 15 Dec 1997

Stathopoulos A M, Cyert M S

Abstract excerpt

Calcineurin is a conserved Ca2+/calmodulin-dependent protein phosphatase that plays a critical role in Ca2+ signaling. We describe new components of a calcineurin-mediated response in yeast, the Ca2+-induced transcriptional activation of FKS2, which encodes a beta-1,3 glucan synthase. A 24-bp reg...

Topics

Amino Acid Sequence
Calcineurin
DNA-Binding Proteins
Gene Expression Regulation, Fungal
Genes, Reporter
Glucosyltransferases
Membrane Proteins
Molecular Sequence Data
Mutation
Phenotype
Plasmids
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae Proteins

Trans-Activators

Transcription Factors

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 9407035
DOI: 10.1101/gad.11.24.3432
PMCID: PMC316814

Genes

TCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9407035-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast.PMID 9407035Read ↗

CRZ1, a target of the calcineurin pathway in Candida albicans.Semantic proximity Read ↗

The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p.Semantic proximity Read ↗

Regulation of salt tolerance by Torulaspora delbrueckii calcineurin target Crz1p.Semantic proximity Read ↗

Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans.Semantic proximity Read ↗

Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site.Semantic proximity Read ↗

Calcineurin Regulatory Subunit Calcium-Binding Domains Differentially Contribute to Calcineurin Signaling in Saccharomyces cerevisiae.Semantic proximity Read ↗

RNA sequencing reveals an additional Crz1-binding motif in promoters of its target genes in the human fungal pathogen Candida albicans.Semantic proximity Read ↗

Updating Insights into the Regulatory Mechanisms of Calcineurin-Activated Transcription Factor Crz1 in Pathogenic FungiSemantic proximity Read ↗

A conserved family of calcineurin regulators.Semantic proximity Read ↗

Identification of possible targets of the Aspergillus fumigatus CRZ1 homologue, CrzA.Semantic proximity Read ↗

Drafting Penicillium oxalicum calcineurin-CrzA pathway by combining the analysis of phenotype, transcriptome, and endogenous protein-protein interactions.Semantic proximity Read ↗

Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase.Semantic proximity Read ↗

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