Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase.

doi:10.1128/MCB.15.8.4103

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Article

Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase.

Molecular and cellular biology - 1 Aug 1995

Garrett-Engele P, Moilanen B, Cyert M S

Abstract excerpt

Calcineurin is a conserved Ca2+/calmodulin-dependent protein phosphatase that plays a critical role in Ca(2+)-mediated signaling in many cells. Yeast cells lacking functional calcineurin (cna1 cna2 or cnb1 mutants) display growth defects under specific environmental conditions, for example, in the presence of high concentrations of Na+, Li+, Mn2+, or OH- but are indistinguishable from wild-type cells under...

Topics

Amino Acid Sequence
Base Sequence
Calcineurin
Calcium-Calmodulin-Dependent Protein Kinases
Calmodulin-Binding Proteins
Chromosome Mapping
Cyclosporine
Echinocandins
Fungal Proteins
Genetic Complementation Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glucosyltransferases

Homeostasis

Membrane Proteins

Molecular Sequence Data

Phenotype

Phosphoprotein Phosphatases

Protein Kinase C

Proton-Translocating ATPases

Source

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Identifiers

PMID: 7542741
DOI: 10.1128/MCB.15.8.4103
PMCID: PMC230649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7542741-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase.PMID 7542741Read ↗

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