Article
Mice transgenic for human CD4 and CCR5 are susceptible to HIV infection.
Proceedings of the National Academy of Sciences of the United States of America - 23 Dec 1997
Browning J, Horner J W, Pettoello-Mantovani M, Raker C, Yurasov S, DePinho R A, Goldstein H
Abstract excerpt
HIV entry into human cells is mediated by CD4 acting in concert with one of several members of the chemokine receptor superfamily. The resistance to HIV infection observed in individuals with defective CCR5 alleles indicated that this particular chemokine receptor plays a crucial role in the initiation of in vivo HIV infection. Expression of human CD4 transgene does not render mice susceptible to HIV infection...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.