Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The gene encoding the elongation factor P protein is essential for viability and is required for protein synthesis.

The Journal of biological chemistry - 19 Dec 1997

Aoki H, Dekany K, Adams S L, Ganoza M C

Abstract excerpt

Elongation factor P (EFP) is a protein that stimulates the peptidyltransferase activity of fully assembled 70 S prokaryotic ribosomes and enhances the synthesis of certain dipeptides initiated by N-formylmethionine. This reaction appears conserved throughout species and is promoted in eukaryotic...

Topics

Chromosomes, Bacterial
Escherichia coli
Gene Expression Regulation
Kanamycin Resistance
Peptide Elongation Factors
Phenotype
Protein Biosynthesis
Proteins
Recombination, Genetic
Replication Origin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9405429
DOI: 10.1074/jbc.272.51.32254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9405429-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The gene encoding the elongation factor P protein is essential for viability and is required for protein synthesis.PMID 9405429Read ↗

Neisseria meningitidis Translation Elongation Factor P and Its Active-Site Arginine Residue Are Essential for Cell ViabilitySemantic proximity Read ↗

Spatial Distribution and Ribosome-Binding Dynamics of EF-P in Live Escherichia coli.Semantic proximity Read ↗

Alterations in the peptidyltransferase and decoding domains of ribosomal RNA suppress mutations in the elongation factor G gene.Semantic proximity Read ↗

Functional analysis of the signal recognition particle in Escherichia coli by characterization of a temperature-sensitive ffh mutant.Semantic proximity Read ↗

The defective phosphoribosyl diphosphate synthase in a temperature-sensitive prs-2 mutant of Escherichia coli is compensated by increased enzyme synthesis.Semantic proximity Read ↗

Importance of the 5 S rRNA-binding ribosomal proteins for cell viability and translation in Escherichia coli.Semantic proximity Read ↗

Generation of pre-tRNAs from polycistronic operons is the essential function of RNase P in Escherichia coli.Semantic proximity Read ↗

Loss of elongation factor P disrupts bacterial outer membrane integrity.Semantic proximity Read ↗

Identification of Substrates of Cytoplasmic Peptidyl-Prolyl Cis/Trans Isomerases and Their Collective Essentiality in Escherichia Coli.Semantic proximity Read ↗

Escherichia coli mrsC is an allele of hflB, encoding a membrane-associated ATPase and protease that is required for mRNA decay.Semantic proximity Read ↗

Overproduction of DnaE protein (alpha subunit of DNA polymerase III) restores viability in a conditionally inviable Escherichia coli strain deficient in DNA polymerase I.Semantic proximity Read ↗

Studies on the role of the metK gene product of Escherichia coli K-12.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.