Article
Loss of elongation factor P disrupts bacterial outer membrane integrity.
Journal of bacteriology - 1 Jan 2012
Zou S Betty, Hersch Steven J, Roy Hervé, Wiggers J Brad, Leung Andrea S, Buranyi Stephen, Xie Jinglin Lucy, Dare Kiley, Ibba Michael, Navarre William Wiley
Abstract excerpt
Elongation factor P (EF-P) is posttranslationally modified at a conserved lysyl residue by the coordinated action of two enzymes, PoxA and YjeK. We have previously established the importance of this modification in Salmonella stress resistance. Here we report that, like poxA and yjeK mutants, Salmonella strains lacking EF-P display increased susceptibility to hypoosmotic conditions, antibiotics, and detergents...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Cell Membrane
- Detergents
- Drug Resistance, Bacterial
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Mutation
- Osmolar Concentration
- Peptide Elongation Factors