Article
The defective phosphoribosyl diphosphate synthase in a temperature-sensitive prs-2 mutant of Escherichia coli is compensated by increased enzyme synthesis.
Microbiology (Reading, England) - 1 Feb 1996
Post David A, Switzer Robert L, Hove-Jensen Bjarne
Abstract excerpt
An Escherichia coli strain which is temperature-sensitive for growth due to a mutation (prs-2) causing a defective phosphoribosyl diphosphate (PRPP) synthase has been characterized. The temperature-sensitive mutation was mapped to a 276 bp HindIII-BssHII DNA fragment located within the open readi...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Chromosome Mapping
- Cloning, Molecular
- Escherichia coli
- Genes, Bacterial
- Humans
- Molecular Sequence Data
- Phenotype
- Point Mutation
- Protein Biosynthesis
- Ribose-Phosphate Pyrophosphokinase
- Sequence Homology, Amino Acid
- Temperature
- Transcription, Genetic