Article
Effect of genetic variation on the fatty acid-binding properties of human serum albumin and proalbumin.
Biochimica et biophysica acta - 17 Oct 1997
Nielsen H, Kragh-Hansen U, Minchiotti L, Galliano M, Brennan S O, Tárnoky A L, Franco M H, Salzano F M, Sugita O
Abstract excerpt
In the circulation, non-esterified fatty acids are transported by albumin which also facilitates their removal from donor cells and uptake into receptor cells. We have studied whether genetic variations in the albumin molecule can affect its in vivo fatty acid-binding properties. The fatty acids bound to 25 structurally different variants and to their wildtype counterparts, isolated from heterozygous carriers,...
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