Article
Structural analysis, fatty acid and thyroxine binding properties of Vancouver and Naskapi variants of human serum albumin.
Clinical biochemistry - 1 Nov 2003
Campagnoli Monica, Kragh-Hansen Ulrich, Overgaard Pedersen Anders, Amoresano Angela, Lyon Andrew W, Cesati Roberto, Sala Alberto, Romano Assunta, Galliano Monica, Minchiotti Lorenzo
Abstract excerpt
OBJECTIVES: To purify and structurally identify two albumin variants found in the Canadian population of native Amerindian origin. To assess the ability of variant albumins to bind lauric acid and L-thyroxine. METHODS: The structural characterization of the alloalbumins was performed by conventional protein chemistry methods and by mass spectrometric analysis. Lauric acid and L-thyroxine affinities to variant...
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