Article
Structural characterization, stability and fatty acid-binding properties of two French genetic variants of human serum albumin.
Biochimica et biophysica acta - 12 Apr 1999
Minchiotti L, Kragh-Hansen U, Nielsen H, Hardy E, Mercier A Y, Galliano M
Abstract excerpt
Four bisalbuminemic, unrelated persons were found in Bretagne, France, and their variant and normal albumins were isolated by DEAE ion exchange chromatography, reduced, carboxymethylated and treated with CNBr. Comparative two-dimensional electrophoresis of the CNBr digests showed that three of the variants were modified in fragment CB4, whereas the fourth had an abnormal fragment CB1. These fragments were...
Topics
- Fatty Acids
- France
- Genetic Variation
- Humans
- Molecular Structure
- Mutation
- Serum Albumin