Article
Locating high-affinity fatty acid-binding sites on albumin by x-ray crystallography and NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2005
Simard J R, Zunszain P A, Ha C-E, Yang J S, Bhagavan N V, Petitpas I, Curry S, Hamilton J A
Abstract excerpt
Human serum albumin (HSA) is a versatile transport protein for endogenous compounds and drugs. To evaluate physiologically relevant interactions between ligands for the protein, it is necessary to determine the locations and relative affinities of different ligands for their binding site(s). We present a site-specific investigation of the relative affinities of binding sites on HSA for fatty acids (FA), the...
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