Article
Mitochondrial mutational spectra in human cells and tissues.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 1997
Khrapko K, Coller H A, André P C, Li X C, Hanekamp J S, Thilly W G
Abstract excerpt
We have found that human organs such as colon, lung, and muscle, as well as their derived tumors, share nearly all mitochondrial hotspot point mutations. Seventeen hotspots, primarily G --> A and A --> G transitions, have been identified in the mitochondrial sequence of base pairs 10,030-10,130....
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