Article
A ribozyme-mediated, gene "knockdown" strategy for the identification of gene function in zebrafish.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 1997
Xie Y, Chen X, Wagner T E
Abstract excerpt
The zebrafish system offers many unique opportunities for the study of molecular biology. To date, only random mutagenesis, and not directed gene knockouts, have been demonstrated in this system. To more fully develop the potential of the zebrafish system, an approach to effectively inhibit the expression of any targeted gene in the developing zebrafish embryo has been developed. This approach uses a transient,...
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