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Article

p53 activation by knockdown technologies.

PLoS genetics - 25 May 2007

Robu Mara E, Larson Jon D, Nasevicius Aidas, Beiraghi Soraya, Brenner Charles, Farber Steven A, Ekker Stephen C

Abstract excerpt

Morpholino phosphorodiamidate antisense oligonucleotides (MOs) and short interfering RNAs (siRNAs) are commonly used platforms to study gene function by sequence-specific knockdown. Both technologies, however, can elicit undesirable off-target effects. We have used several model genes to study these effects in detail in the zebrafish, Danio rerio. Using the zebrafish embryo as a template, correct and mistargeting...

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Identifiers

PMID: 17530925
DOI: 10.1371/journal.pgen.0030078
PMCID: PMC1877875

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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