Article
Insulin-like growth factor binding protein-5 modulates muscle differentiation through an insulin-like growth factor-dependent mechanism.
The Journal of cell biology - 1 May 1996
James P L, Stewart C E, Rotwein P
Abstract excerpt
The insulin-like growth factor binding proteins (IGFBPs) are a family of six secreted proteins which bind to and modulate the actions of insulin-like growth factors-I and -II (IGF-I and -II). IGFBP-5 is more conserved than other IGFBPs characterized to date, and is expressed in adult rodent muscl...
Topics
- Animals
- Antisense Elements (Genetics)
- Blotting, Western
- Cell Differentiation
- Cell Line
- DNA, Complementary
- Extracellular Matrix
- Gene Expression
- Insulin-Like Growth Factor Binding Protein 5
- Insulin-Like Growth Factor I
- Mice
- Muscle Fibers, Skeletal
- Myogenin
- Phenotype
- Plasmids
- Transcription, Genetic
- Transfection
- Transgenes