Molecular genetic aspects of human mitochondrial disorders.

doi:10.1146/annurev.ge.29.120195.001055

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Article

Molecular genetic aspects of human mitochondrial disorders.

Annual review of genetics - 1 Jan 1995

Larsson N G, Clayton D A

Abstract excerpt

This review focuses on mutations of mitochondrial DNA (mtDNA) which are an important cause of mitochondrial disorders in humans and are also associated with common neurodegenerative disorders and aging. The high copy number of mtDNA and its maternal transmission make the inheritance of mtDNA muta...

Topics

Animals
Cell Nucleus
DNA, Mitochondrial
Electron Transport
Gene Deletion
Genetics, Medical
Genome, Human
Humans
Multigene Family
Mutation
Proteins
RNA, Transfer

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