Article
Molecular epidemiology of hereditary nonpolyposis colorectal cancer in Finland.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer - 1 Jan 1998
Aaltonen L A
Abstract excerpt
The population frequency of germline mutations predisposing to hereditary nonpolyposis colorectal cancer (HNPCC) is unknown. Several epidemiological studies have addressed the problem, and estimates on the proportion of the total colorectal cancer burden accounted for by HNPCC have varied between 0.5% and 13%. In the absence of any clinical diagnostic hallmarks, the definition of HNPCC is based on family history....
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