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Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-α signaling

21 Mar 2017

Abstract excerpt

Significance Type 1 diabetes (T1D) is an increasing medical health problem caused by autoimmune T cells killing insulin-producing β cells in the islets of Langerhans. When the majority of β cells are destroyed, unless exogenous insulin is administered, ketoacidosis and death follow. However, providing exogenous insulin does not prevent the resultant complications of stroke, heart disease, visual impairment, or...

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PMID: 28325871
DOI: 10.1073/pnas.1700878114

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