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Article

Factor V Leiden (R506Q) and risk of venous thromboembolism: a case-control study based on the Spanish population.

Clinical genetics - 1 Oct 1997

García-Gala J M, Alvarez V, Pinto C R, Soto I, Urgellés M F, Menéndez M J, Carracedo C, López-Larrea C, Coto E

Abstract excerpt

Resistance to activated protein C (APC) is a frequent cause of thrombophilia. Most patients showing APC-resistance have a G to A mutation at codon 506 of the factor V that converts arginine to glutamine. This mutation is present in populations worldwide with frequencies ranging from 0.01 to 0.05. Genotyping of 150 control individuals from the Spanish population showed that 3.33% of them carried the mutation....

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Source

Identifiers

PMID: 9383024
DOI: 10.1111/j.1399-0004.1997.tb02548.x

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Factor V Leiden (R506Q) and risk of venous thromboembolism: a case-control study based on the Spanish population.PMID 9383024Read ↗

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Inherited resistance to activated protein C caused by presence of the FV:Q506 allele as a basis of venous thrombosis.Semantic proximity Read ↗

Activated protein C resistance due to a common factor V gene mutation is a major risk factor for venous thrombosis.Semantic proximity Read ↗

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