Article
A virus-neutralizing epitope on the glycoprotein of rabies virus that contains Trp251 is a linear epitope.
Virus research - 1 Sept 1997
Luo T R, Minamoto N, Ito H, Goto H, Hiraga S, Ito N, Sugiyama M, Kinjo T
Abstract excerpt
We have established a hybridoma producing monoclonal antibody (MAb) against a linear epitope of glycoprotein (G protein) of the RC-HL strain of rabies virus. This MAb15-13 showed almost the same neutralizing activity to all of five rabies fixed strains, including RC-HL, and reacted to the denatur...
Topics
- Animals
- Antibodies, Monoclonal
- Antibodies, Viral
- Antigens, Viral
- Epitopes
- GTP-Binding Proteins
- Genetic Variation
- Glycoproteins
- Mice
- Mice, Inbred BALB C
- Mutagenesis, Site-Directed
- Neutralization Tests
- Point Mutation
- Rabies virus
- Sequence Analysis, DNA
- Tryptophan