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Article

Studies on the escape mutants of rabies virus which are resistant to neutralization by a highly conserved conformational epitope-specific monoclonal antibody #1-46-12.

Microbiology and immunology - 1 Jan 2002

Irie Takashi, Matsuda Yukihiro, Honda Yoshikazu, Morimoto Kinjiro, Kawai Akihiko

Abstract excerpt

We investigated a virus-neutralizing conformational epitope of the rabies virus glycoprotein (G) that is recognized by an anti-G monoclonal antibody (mAb; #1-46-12) and shared by most of the laboratory strains of the virus. To investigate the epitope structure, we isolated escape mutants from the HEP-Flury virus (wild-type; wt) after repeated passages in culture in the presence of the mAb. Immunofluorescence...

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Identifiers

PMID: 12222931
DOI: 10.1111/j.1348-0421.2002.tb02719.x

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