Article
Generation of a novel live rabies vaccine strain with a high level of safety by introducing attenuating mutations in the nucleoprotein and glycoprotein.
Vaccine - 9 Oct 2017
Nakagawa Keisuke, Nakagawa Kento, Omatsu Tsutomu, Katayama Yukie, Oba Mami, Mitake Hiromichi, Okada Kazuma, Yamaoka Satoko, Takashima Yasuhiro, Masatani Tatsunori, Okadera Kota, Ito Naoto, Mizutani Tetsuya, Sugiyama Makoto
Abstract excerpt
The current live rabies vaccine SAG2 is attenuated by only one mutation (Arg-to-Glu) at position 333 in the glycoprotein (G333). This fact generates a potential risk of the emergence of a pathogenic revertant by a back mutation at this position during viral propagation in the body. To circumvent this risk, it is desirable to generate a live vaccine strain highly and stably attenuated by multiple mutations....
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