Structural and immunological characterization of a linear virus-neutralizing epitope of the rabies virus glycoprotein and its possible use in a synthetic vaccine.

doi:10.1128/JVI.64.8.3804-3809.1990

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Article

Structural and immunological characterization of a linear virus-neutralizing epitope of the rabies virus glycoprotein and its possible use in a synthetic vaccine.

Journal of virology - 1 Aug 1990

Dietzschold B, Gore M, Marchadier D, Niu H S, Bunschoten H M, Otvos L, Wunner W H, Ertl H C, Osterhaus A D, Koprowski H

Abstract excerpt

We have mapped a linear epitope recognized by the virus-neutralizing monoclonal antibody 6-15C4 within the primary sequence of the G protein from the Evelyn-Rokitnicki-Abelseth strain of rabies virus. This was accomplished by using fragments of the rabies virus G protein and deduced amino acid sequences of neutralization-resistant variant rabies viruses. The monoclonal antibody 6-15C4 specifically recognized a...

Topics

Amino Acid Sequence
Antibodies, Monoclonal
Antibodies, Viral
Antibody Formation
Antigens, Viral
Base Sequence
Epitopes
Genes, Viral
Genetic Variation
Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocyte Activation

Molecular Sequence Data

Neutralization Tests

Peptides

RNA, Viral

Rabies virus

T-Lymphocytes, Helper-Inducer

Vaccines, Synthetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1695255
DOI: 10.1128/JVI.64.8.3804-3809.1990
PMCID: PMC249675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1695255-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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