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Amino Acid Mutation in Position 349 of Glycoprotein Affect the Pathogenicity of Rabies Virus

3 Apr 2020

Abstract excerpt

Rabies, caused by rabies virus (RABV), is a zoonotic disease infecting mammals including humans. Studies have confirmed that glycoprotein (G) is most related to RABV pathogenicity. In the present study, to discover more amino acid sites related to viral pathogenicity, artificial mutants have been constructed in G of virulent strain GD-SH-01 backbone. Results showed that pathogenicity of GD-SH-01 significantly...

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PMID: 32308648
DOI: 10.3389/fmicb.2020.00481

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