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Article

Altered cell surface expression and signaling of leptin receptors containing the fatty mutation.

The Journal of biological chemistry - 17 Jul 1998

Crouse J A, Elliott G E, Burgess T L, Chiu L, Bennett L, Moore J, Nicolson M, Pacifici R E

Abstract excerpt

Leptin and the leptin receptor are key players in the regulation of body weight. In an attempt to dissect the molecular mechanism of the Zucker fatty rat leptin receptor mutation (Gln269 --> Pro) we analyzed the effects of this mutation on leptin receptor signaling and expression in three different expression systems: 1) 32D cells expressing leptin/erythropoietin receptor chimeras, 2) COS-7 cells expressing a...

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Identifiers

PMID: 9660803
DOI: 10.1074/jbc.273.29.18365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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