Article
Altered cell surface expression and signaling of leptin receptors containing the fatty mutation.
The Journal of biological chemistry - 17 Jul 1998
Crouse J A, Elliott G E, Burgess T L, Chiu L, Bennett L, Moore J, Nicolson M, Pacifici R E
Abstract excerpt
Leptin and the leptin receptor are key players in the regulation of body weight. In an attempt to dissect the molecular mechanism of the Zucker fatty rat leptin receptor mutation (Gln269 --> Pro) we analyzed the effects of this mutation on leptin receptor signaling and expression in three differe...
Topics
- Animals
- COS Cells
- Carrier Proteins
- Flow Cytometry
- Leptin
- Ligands
- Mutation
- Obesity
- Proteins
- Rats
- Rats, Zucker
- Receptors, Cell Surface
- Receptors, Erythropoietin
- Receptors, Leptin
- Recombinant Fusion Proteins
- Signal Transduction
- Surface Properties