Article
GSTT1-dependent induction of centromere-negative and -positive micronuclei by 1,2:3,4-diepoxybutane in cultured human lymphocytes.
Mutagenesis - 1 Sept 1997
Vlachodimitropoulos D, Norppa H, Autio K, Catalán J, Hirvonen A, Tasa G, Uusküla M, Demopoulos N A, Sorsa M
Abstract excerpt
The role of the glutathione S-transferase T1 gene (GSTT1) in determining genotoxic response to 1,2:3,4-diepoxybutane (DEB), an epoxide metabolite of 1,3-butadiene, was studied by analysis of micronuclei (MN) in cultured human lymphocytes using the cytokinesis block method. Fluorescence in situ hybridization (FISH) with an alphoid satellite DNA probe specific for the centromeres of all human chromosomes was...
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