Article
Role of GSTT1 and GSTM1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes.
Carcinogenesis - 1 Jun 1995
Norppa H, Hirvonen A, Järventaus H, Uusküla M, Tasa G, Ojajärvi A, Sorsa M
Abstract excerpt
The individual genotoxic response of cultured human lymphocytes to diepoxybutane (DEB), an epoxide metabolite of 1,3-butadiene, shows a bimodal distribution. Blood donors can be classified as either DEB-sensitive or DEB-resistant on the basis of the frequency of sister chromatid exchanges (SCEs)...
Topics
- Adult
- Cells, Cultured
- Epoxy Compounds
- Female
- Genotype
- Glutathione Transferase
- Humans
- In Vitro Techniques
- Lymphocytes
- Male
- Middle Aged
- Mutagens
- Sister Chromatid Exchange