Induction of chromosome-specific aneuploidy and micronuclei in human lymphocytes by metabolites of 1,3-butadiene.

doi:10.1093/carcin/18.9.1687

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Article

Induction of chromosome-specific aneuploidy and micronuclei in human lymphocytes by metabolites of 1,3-butadiene.

Carcinogenesis - 1 Sept 1997

Xi L, Zhang L, Wang Y, Smith M T

Abstract excerpt

1,3-Butadiene is a carcinogen in rodents, but its potential carcinogenicity to humans remains controversial. Numerous studies have shown that butadiene and its metabolites cause sister chromatid exchanges in vitro and in vivo. To test for other types of genotoxicity, the micronucleus assay and fl...

Topics

Aneuploidy
Butadienes
Carcinogens
Cells, Cultured
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 7
Diploidy
Epoxy Compounds
Genotype
Glutathione Transferase
Humans
Interphase
Lymphocytes
Male
Metaphase
Micronuclei, Chromosome-Defective
Micronucleus Tests

Source

Open in PubMed

Identifiers

PMID: 9328162
DOI: 10.1093/carcin/18.9.1687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9328162-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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