Thyroid hormone receptor dimerization is required for dominant negative inhibition by mutations that cause thyroid hormone resistance.

Article

Thyroid hormone receptor dimerization is required for dominant negative inhibition by mutations that cause thyroid hormone resistance.

The Journal of biological chemistry - 25 Jul 1993

Nagaya T, Jameson J L

Abstract excerpt

The syndrome of thyroid hormone resistance (THR) is caused by multiple distinct mutations of the ligand-binding domain of the thyroid hormone beta receptor. Although the mutant receptors are transcriptionally inactive, they inhibit normal receptor function in a dominant negative manner to cause h...

Topics

Amino Acid Sequence
Base Sequence
Cells, Cultured
DNA
Humans
Molecular Sequence Data
Mutation
Polymers
Receptors, Thyroid Hormone
Thyroid Diseases
Thyroid Hormones

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