Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thyroid hormone resistance syndrome: correlation of dominant negative activity and location of mutations.

The Journal of clinical endocrinology and metabolism - 1 Oct 1993

Nagaya T, Eberhardt N L, Jameson J L

Abstract excerpt

Generalized resistance to thyroid hormone (GRTH) is caused by multiple distinct mutations that cluster in two regions of the hormone-binding domain of the thyroid hormone beta-receptor. The mutant receptors are functionally inactive, but nevertheless inhibit normal receptor activity in a dominant negative manner. Four different GRTH mutants were studied in the transient expression assays to further examine their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cells, Cultured
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Molecular Sequence Data

Share to Mutation

Share to Phenotype

Share to Transcription, Genetic

Source

Identifiers

PMID: 8408475
DOI: 10.1210/jcem.77.4.8408475

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thyroid hormone resistance syndrome: correlation of dominant negative activity and location of mutations.PMID 8408475Read ↗

Thyroid hormone receptor mutants that cause resistance to thyroid hormone. Evidence for receptor competition for DNA sequences in target genes.Semantic proximity Read ↗

New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone.Semantic proximity Read ↗

Variable transcriptional activity and ligand binding of mutant beta 1 3,5,3'-triiodothyronine receptors from four families with generalized resistance to thyroid hormone.Semantic proximity Read ↗

Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific.Semantic proximity Read ↗

Resistance to thyroid hormone.Semantic proximity Read ↗

Thyroid hormone resistance syndrome. Inhibition of normal receptor function by mutant thyroid hormone receptors.Semantic proximity Read ↗

Kindred S thyroid hormone receptor is an active and constitutive silencer and a repressor for thyroid hormone and retinoic acid responses.Semantic proximity Read ↗

Mechanisms by which thyroid hormone receptor mutations cause clinical syndromes of resistance to thyroid hormone.Semantic proximity Read ↗

Molecular diagnosis and characterization of thyroid hormone resistance syndromes.Semantic proximity Read ↗

Thyroid hormone resistance.Semantic proximity Read ↗

Resistance to thyroid hormone and its molecular basis.Semantic proximity Read ↗

Dominant negative transcriptional regulation by a mutant thyroid hormone receptor-beta in a family with generalized resistance to thyroid hormone.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.