Article
An in vitro analysis of the combination of hemophilia A and factor V(LEIDEN).
Blood - 15 Oct 1997
van 't Veer C, Golden N J, Kalafatis M, Simioni P, Bertina R M, Mann K G
Abstract excerpt
The classification of factor VIII deficiency, generally used based on plasma levels of factor VIII, consists of severe (<1% normal factor VIII activity), moderate (1% to 4% factor VIII activity), or mild (5% to 25% factor VIII activity). A recent communication described four individuals bearing identical factor VIII mutations. This resulted in a severe bleeding disorder in two patients who carried a normal factor...
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