Article
Mild hemophilia A with factor VIII assay discrepancy: using thrombin generation assay to assess the bleeding phenotype.
Journal of thrombosis and haemostasis : JTH - 1 Mar 2008
Trossaërt M, Regnault V, Sigaud M, Boisseau P, Fressinaud E, Lecompte T
Abstract excerpt
INTRODUCTION: In some patients with mild hemophilia A, there are discrepancies between 1-stage (1-st) and 2-stage (2-st) factor VIII (FVIII) clotting assays, and also chromogenic assays for FVIII activity (FVIII:C). We examined whether thrombography could provide a better evaluation of the hemostatic status of these patients. METHODS: Two families with such discrepancies and markedly contrasting clinical...
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