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Article

Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2011

Ninivaggi M, Dargaud Y, van Oerle R, de Laat B, Hemker H C, Lindhout T

Abstract excerpt

BACKGROUND: The available methods for measuring factor VIII (FVIII) activity suffer reportedly from lack of sensitivity and precision in the < 1 IU dL(-1) range. This precludes correlation of clinical phenotype with FVIII levels. OBJECTIVES: To study a possible association between clinical phenotype in patients with FVIII levels < 1 IU dL(-1). METHODS/RESULTS: The FIXa-driven FVIII assay (FVIII-CAT) has a...

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Source

Identifiers

PMID: 21605333
DOI: 10.1111/j.1538-7836.2011.04358.x

Genes

CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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