Article
Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis.
Science (New York, N.Y.) - 29 Apr 1994
Dranoff G, Crawford A D, Sadelain M, Ream B, Rashid A, Bronson R T, Dickersin G R, Bachurski C J, Mark E L, Whitsett J A
Abstract excerpt
The in vivo function of murine granulocyte-macrophage colony-stimulating factor (GM-CSF) was investigated in mice, carrying a null allele of the GM-CSF gene, that were generated by gene targeting techniques in embryonic stem cells. Although steady-state hematopoiesis was unimpaired in homozygous mutant animals, all animals developed the progressive accumulation of surfactant lipids and proteins in the alveolar...
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