Article
Developmental roles of the retinoic acid receptors.
The Journal of steroid biochemistry and molecular biology - 1 Jun 1995
Lohnes D, Mark M, Mendelsohn C, Dollé P, Decimo D, LeMeur M, Dierich A, Gorry P, Chambon P
Abstract excerpt
Retinoic acid, one of the principle active metabolites of vitamin A (retinol), is believed to be essential for numerous developmental and physiological processes. Vitamin A deprivation (VAD) during development leads to numerous congenital defects. Previous studies of retinoic acid receptor (RAR) deficient mice failed to reveal any of these VAD-induced defects. This finding suggested that either the RARs are...
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