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Article

CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes.

Circulation research - 14 Aug 2009

MacDonnell Scott M, Weisser-Thomas Jutta, Kubo Hajime, Hanscome Marie, Liu Qinghang, Jaleel Naser, Berretta Remus, Chen Xiongwen, Brown Joan H, Sabri Abdel-Karim, Molkentin Jeffery D, Houser Steven R

Abstract excerpt

RATIONALE: Pathological cardiac myocyte hypertrophy is thought to be induced by the persistent increases in intracellular Ca(2+) needed to maintain cardiac function when systolic wall stress is increased. Hypertrophic Ca(2+) binds to calmodulin (CaM) and activates the phosphatase calcineurin (Cn) and CaM kinase (CaMK)II. Cn dephosphorylates cytoplasmic NFAT (nuclear factor of activated T cells), inducing its...

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Identifiers

PMID: 19608982
DOI: 10.1161/CIRCRESAHA.109.194035
PMCID: PMC2765687

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Source receipt: pubmed, retrieved 7 Sept 2026.

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