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Bruton's Tyrosine Kinase Is Essential for Human B Cell Tolerance

4 Oct 2004

Abstract excerpt

Most polyreactive and antinuclear antibodies are removed from the human antibody repertoire during B cell development. To elucidate how B cell receptor (BCR) signaling may regulate human B cell tolerance, we tested the specificity of recombinant antibodies from single peripheral B cells isolated from patients suffering from X-linked agammaglobulinemia (XLA). These patients carry mutations in the Bruton's tyrosine...

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PMID: 15466623
DOI: 10.1084/jem.20040920

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