Article
Overexpression of catalase in myeloid cells causes impaired postischemic neovascularization.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2011
Hodara Roberto, Weiss Daiana, Joseph Giji, Velasquez-Castano Juan C, Landázuri Natalia, Han Ji Woong, Yoon Young-sup, Taylor W Robert
Abstract excerpt
OBJECTIVE: Myeloid lineage cells (MLCs) such as macrophages are known to play a key role in postischemic neovascularization. However, the role of MLC-derived reactive oxygen species in this process and their specific chemical identity remain unknown. METHODS AND RESULTS: Transgenic mice with MLC-specific overexpression of catalase (Tg(Cat-MLC) mice) were created on a C57BL/6 background. Macrophage catalase...
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