Overexpression of catalase in myeloid cells causes impaired postischemic neovascularization.

doi:10.1161/ATVBAHA.111.233247

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Article

Overexpression of catalase in myeloid cells causes impaired postischemic neovascularization.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2011

Hodara Roberto, Weiss Daiana, Joseph Giji, Velasquez-Castano Juan C, Landázuri Natalia, Han Ji Woong, Yoon Young-sup, Taylor W Robert

Abstract excerpt

OBJECTIVE: Myeloid lineage cells (MLCs) such as macrophages are known to play a key role in postischemic neovascularization. However, the role of MLC-derived reactive oxygen species in this process and their specific chemical identity remain unknown. METHODS AND RESULTS: Transgenic mice with MLC-specific overexpression of catalase (Tg(Cat-MLC) mice) were created on a C57BL/6 background. Macrophage catalase...

Topics

Animals
Capillaries
Catalase
Cell Movement
Cells, Cultured
Collateral Circulation
Disease Models, Animal
Endothelial Cells
Femoral Artery
Genotype
Hindlimb

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hydrogen Peroxide

Inflammation Mediators

Ischemia

Laser-Doppler Flowmetry

Ligation

Male

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Identifiers

PMID: 21799178
DOI: 10.1161/ATVBAHA.111.233247
PMCID: PMC3880802

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