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Article

TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration.

Neurobiology of disease - 1 Jul 2008

Kilic Ulkan, Kilic Ertugrul, Matter Christian M, Bassetti Claudio L, Hermann Dirk M

Abstract excerpt

The pattern recognition receptor toll-like receptor (TLR)-4 mediates innate danger signaling in the brain, being activated in response to lipopolysaccharide. Until now, its role in the degenerating brain remained unknown. We here examined effects of a loss-of-function mutation of TLR-4 in mice submitted to transient focal cerebral ischemia and retinal ganglion cell (RGC) axotomy, which are highly reproducible and...

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Identifiers

PMID: 18486483
DOI: 10.1016/j.nbd.2008.03.002

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MPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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