Article
A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.
The Journal of biological chemistry - 21 Nov 1997
Li L, Ernsting B R, Wishart M J, Lohse D L, Dixon J E
Abstract excerpt
In Saccharomyces cerevisiae the CDC14 gene is essential for cell cycle progression. Strains carrying the cdc14-1(ts) allele enter the cell cycle and arrest at restrictive temperatures. We have identified two human cDNAs encoding proteins which share sequence identity to the yeast CDC14p. The cell cycle arrest in cdc14-1(ts) can be specifically complemented by the human cDNAs suggesting that they are functionally...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.