Article
Lack of the Polycomb-group gene rae28 causes maturation arrest at the early B-cell developmental stage.
Experimental hematology - 1 Jan 2001
Tokimasa S, Ohta H, Sawada A, Matsuda Y, Kim J Y, Nishiguchi S, Hara J, Takihara Y
Abstract excerpt
The rae28 gene (rae28) is a murine homologue of the Drosophila polyhomeotic gene, which is a member of the Polycomb-group genes. In this study, we examined the role of rae28 in lymphocyte development. Because homozygous rae28-deficient (rae28-/-) mice died in the perinatal period, we examined lymphocyte development by generating chimeric mice reconstituted with green fluorescence protein-labeled mutant fetal...
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