Article
Expression of p53 protein in advanced head and neck squamous cell carcinoma before and after chemotherapy.
Archives of otolaryngology--head & neck surgery - 1 Nov 1997
Dunphy C H, Dunphy F R, Boyd J H, Varvares M A, Kim H J, Lowe V, Dunleavy T L, Rodriguez J, McDonough E M, Minster J
Abstract excerpt
BACKGROUND: The expression of p53 protein has been reported to be in the range of 35% to 67% in head and neck squamous cell carcinoma (HNSCC). Mutations of the gene for p53 protein have been associated with rapidly proliferating tumors, and p53 protein expression has been shown to be a significant predictor of worse survival in surgically resected HNSCC. To determine whether p53 protein expression in advanced...
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