Article
Expression of p53 protein in advanced head and neck squamous cell carcinoma before and after chemotherapy.
Archives of otolaryngology--head & neck surgery - 1 Nov 1997
Dunphy C H, Dunphy F R, Boyd J H, Varvares M A, Kim H J, Lowe V, Dunleavy T L, Rodriguez J, McDonough E M, Minster J
Abstract excerpt
BACKGROUND: The expression of p53 protein has been reported to be in the range of 35% to 67% in head and neck squamous cell carcinoma (HNSCC). Mutations of the gene for p53 protein have been associated with rapidly proliferating tumors, and p53 protein expression has been shown to be a significan...
Topics
- Adolescent
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
- Carboplatin
- Carcinoma, Squamous Cell
- Drug Administration Schedule
- Head and Neck Neoplasms
- Humans
- Immunohistochemistry
- Middle Aged
- Mutation
- Neoplasm, Residual
- Paclitaxel
- Retrospective Studies