Article
Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jul 1996
Rankin J A, Picarella D E, Geba G P, Temann U A, Prasad B, DiCosmo B, Tarallo A, Stripp B, Whitsett J, Flavell R A
Abstract excerpt
To investigate the contribution of interleukin-4 (IL-4) to airway inflammation in vivo and to explore directly its relationship to airway reactivity, we created transgenic mice in which the murine cDNA for IL-4 was regulated by the rat Clara cell 10 protein promoter. Expression was detected only...
Topics
- Animals
- Bronchoalveolar Lavage Fluid
- DNA, Complementary
- Eosinophils
- Female
- Hypertrophy
- Inflammation
- Interleukin-4
- Lung
- Lymphocytes
- Mice
- Mice, Transgenic
- Organ Specificity
- Phenotype