Article
MCF-7 breast carcinoma cells overexpressing FGF-1 form vascularized, metastatic tumors in ovariectomized or tamoxifen-treated nude mice.
Oncogene - 23 Oct 1997
Zhang L, Kharbanda S, Chen D, Bullocks J, Miller D L, Ding I Y, Hanfelt J, McLeskey S W, Kern F G
Abstract excerpt
FGF-1 is expressed in a high proportion of breast tumors. While overexpression of FGF-4 in the MCF-7 breast carcinoma cell line confers the ability to form spontaneously metastasizing tumors in ovariectomized nude mice without estrogen supplementation and in mice that receive tamoxifen pellets, the response of a cell to individual FGFs can be controlled at multiple levels, and the significance of FGF-1 expression...
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