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Article

Complexes between C-Reactive Protein and Very Low Density Lipoprotein Delay Bacterial Clearance in Sepsis.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2020

Cheng Zhenxing, Abrams Simon T, Toh Julien, Wang Susan S, Downey Colin, Ge Xiaoling, Yu Qian, Yu Weiping, Wang Guozheng, Toh Cheng-Hock

Abstract excerpt

C-reactive protein (CRP) can increase up to 1000-fold in blood and form complexes with very low density lipoproteins (VLDL). These complexes are associated with worse outcomes for septic patients, and this suggests a potential pathological role in sepsis. Complex formation is heightened when CRP is over 200 mg/l and levels are associated with the severity of sepsis and blood bacterial culture positivity. Using a...

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PMID: 32269097
DOI: 10.4049/jimmunol.1900962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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