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Chromosomal Localization, Structure, and Regulation of the <i>UGT2B17</i> Gene, Encoding a C19 Steroid Metabolizing Enzyme

1 Oct 1997

Abstract excerpt

UGT2B17 is a UDP-glucuronosyltransferase enzyme expressed in several extrahepatic steroid target tissues, including the human prostate, where it glucuronidates C19 steroids such as dihydrotestosterone (DHT), androsterone (ADT), and androstane-3alpha, 17beta-diol (3alpha-diol). To determine if UGT2B17 is regulated by physiological effectors of the human prostate, DHT and epidermal growth factor (EGF) were...

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PMID: 9364925
DOI: 10.1089/dna.1997.16.1143

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