Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease Progression

18 Sept 2018

Abstract excerpt

Abstract Purpose: Steroidogenic enzymes are essential for prostate cancer development. Enzymes inactivating potent androgens were not investigated thoroughly, which leads to limited interference strategies for prostate cancer therapy. Here we characterized the clinical relevance, significance, and regulation mechanism of enzyme HSD17B2 in prostate cancer development. Experimental Design: HSD17B2 expression was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogen and related hormone effects
Share to Hormonal and reproductive studies
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30228209
DOI: 10.1158/1078-0432.ccr-18-2392

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease ProgressionPMID 30228209Read ↗

Loss of an Androgen-Inactivating and Isoform-Specific HSD17B4 Splice Form Enables Emergence of Castration-Resistant Prostate CancerSemantic proximity Read ↗

The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression.Semantic proximity Read ↗

The SOX4/miR-17-92/RB1 Axis Promotes Prostate Cancer ProgressionSemantic proximity Read ↗

The impact of germline genetic variations in hydroxysteroid (17-beta) dehydrogenases on prostate cancer outcomes after prostatectomy.Semantic proximity Read ↗

The role of CYP17A1 in prostate cancer development: structure, function, mechanism of action, genetic variations and its inhibition.Semantic proximity Read ↗

HSD3B1 variant and androgen-deprivation therapy outcome in prostate cancer.Semantic proximity Read ↗

Chromosomal Localization, Structure, and Regulation of the <i>UGT2B17</i> Gene, Encoding a C19 Steroid Metabolizing EnzymeSemantic proximity Read ↗

Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolismSemantic proximity Read ↗

HSD3B1 Genotypes Conferring Adrenal-Restrictive and Adrenal-Permissive Phenotypes in Prostate Cancer and BeyondSemantic proximity Read ↗

SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer ProgressionSemantic proximity Read ↗

Genetic variation in the HSD17B1 gene and risk of prostate cancer.Semantic proximity Read ↗

Multi-omics analyses identify HSD17B4 methylation-silencing as a predictive and response marker of HER2-positive breast cancer to HER2-directed therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.