Article
Deletion polymorphism of the UGT2B17 gene is associated with increased risk for prostate cancer and correlated to gene expression in the prostate.
The pharmacogenomics journal - 1 Apr 2008
Karypidis A-H, Olsson M, Andersson S-O, Rane A, Ekström L
Abstract excerpt
Metabolism of androgens includes glucuronidation, the major pathway of steroid elimination in several steroid target tissues. Glucuronidation is catalysed by UDP-glucuronosyltransferases (UGTs). UGT2B17 has been shown to be particularly active against androgens and is highly abundant in the prost...
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