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Article

Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism

17 Jan 2003

Abstract excerpt

BACKGROUND: As androgens play an essential role in prostate cancer, we sought to develop a real-time PCR to characterize mRNA expression profiles of human members of the Aldo-Keto Reductase (AKR) 1C gene family, as well as of 5 alpha-steroid reductase Type II (SRD5A2) in prostate cancer samples. Functional activity and regulation of AKR1C2, a 3 alpha-hydroxysteroid dehydrogenase (HSD) type III, was also assessed...

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Share to Aldose Reductase and Taurine
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PMID: 12539226
DOI: 10.1002/pros.10192

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