Article
Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2006
Park Jong, Chen Lan, Ratnashinge Luke, Sellers Thomas A, Tanner Jean-Paul, Lee Ji-Hyun, Dossett Nicole, Lang Nicholas, Kadlubar Fred F, Ambrosone Christine B, Zachariah Babu, Heysek Randy V, Patterson Stephen, Pow-Sang Julio
Abstract excerpt
PURPOSE: UDP-glucuronosyltransferases (UGT) are a family of enzymes that glucuronidate many endogenous chemicals, including androgens. This makes them more hydrophilic, alters biological activity, and facilitates their excretion. A deletion polymorphism in the UGT2B17 gene was recently described...
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