Estimation of the amount of DNA polymorphism when the neutral mutation rate varies among sites.

doi:10.1093/genetics/147.4.1959

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Article

Estimation of the amount of DNA polymorphism when the neutral mutation rate varies among sites.

Genetics - 1 Dec 1997

Misawa K, Tajima F

Abstract excerpt

Knowing the amount of DNA polymorphism is essential to understand the mechanism of maintaining DNA polymorphism in a natural population. The amount of DNA polymorphism can be measured by the average number of nucleotide differences per site (pi), the proportion of segregating (polymorphic) site (...

Topics

DNA
Models, Genetic
Models, Statistical
Mutation
Polymorphism, Genetic

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